学术研究：冻卵的最佳时机
我是分割线
数据来源：Tolga B. Mesen 医学 博士 Jennifer E. Mersereau 医学博士，MSCI a Jennifer B. Kane 博士 b；Anne Z. Steiner 医学博士、公共卫生 硕士
设计：我们构建了一个决策树模型，以确定在 25-40 岁时保存卵母细胞与不采取任何行动的成功率和成本效益，假设在最初的决定后 3、5 或 7 年尝试生育。
患者：假设患者年龄在 25-40 岁之间，来讨论选择性卵母细胞冷冻保存。
干预措施：决定将卵母细胞从 25 岁冷冻保存至 40 岁，而不是不采取任何行动。
主要成果及措施：初步决定是否冷冻保存卵母细胞后，活产的概率。
结果：37 岁时进行卵母细胞冷冻保存，与不采取任何措施相比，活产概率提高幅度最大（51.6% vs. 21.9%）。34 岁以下进行卵母细胞冷冻保存，活产概率最高（>74%），但 25-30 岁时的卵母细胞冷冻保存与不采取任何措施相比，获益不大（增加 2.6%-7.1%）。37 岁时进行卵母细胞冷冻保存的成本效益最高。
结论：卵母细胞冷冻保存对特定女性来说越早进行，成功率越高。37 岁时，卵母细胞冷冻保存比不采取任何措施的益处最大，而且成本效益最高。
我是分割线
原文详细内容
Abstract
Until recently there was little to offer young women with cancer facing chemotherapy, radiotherapy or surgery and the probability of premature menopause and sterility. The first ‘frozen egg’ baby was born in 1986, but success rates were so low that egg freezing was neglected. Three technological developments in assisted reproduction treatment (intracytoplasmic sperm injection, dehydro-cryoprotectants and vitrification) have transformed this picture and now young women with frozen eggs have the same probability of a live birth per embryo transfer as women undergoing conventional IVF. For many women it is not cancer but the passage of time that denies them a chance of motherhood. Social, educational and financial pressures often lead them to delay starting a family until their late thirties, by which time the chance of success is compromised by low fecundity rates and an increased risk of miscarriage if they become pregnant. Donor eggs are not an option for many because of supply constraints and ethical concerns. Freezing a woman’s eggs at age 30 literally ‘freezes in time’ her fertility potential and gives her the chance of a healthy pregnancy at a time of her choosing. The role of oocyte cryopreservation in the context of social egg freezing is discussed.
Until recently there was little we could offer young women with cancer facing the chemotherapy, radiotherapy or surgery that could save their lives and the certainty of premature menopause and sterility. The first frozen-egg baby was born in 1986, but the success rate (100 eggs to produce one baby) was so low that egg freezing was neglected for years. Three technological developments in assisted reproduction treatment (intracytoplasmic sperm injection, dehydro-cryoprotectants and vitrification) have transformed this picture and now young women who have cryopreserved eggs can be offered the same chance of a live birth per embryo transfer as women undergoing conventional IVF treatment. For many women today it is not cancer but the simple passage of time that robs them of their chance of motherhood. Social, educational, emotional and financial pressures often lead them to delay trying to start a family until their late thirties, by which time the chance of success is very low. Women at age 40 face a 40% chance of miscarriage if they can get pregnant at all and by the age of 45, the risk of miscarriage is 75%. Donor eggs are not an option for many because of supply constraints and ethical and cultural concerns. Freezing a woman’s eggs at age 30 literally ‘freezes in time’ her fertility potential and gives her the chance of a healthy pregnancy at a time of her choosing. This paper discusses the role of oocyte cryopreservation in the context of social egg freezing.
我是分割线
以上文献来源于以下网址，由平台翻译呈现
https://www.sciencedirect.com/science/article/pii/S0015028215001703
